Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …

Mitochondria are ubiquitous intracellular organelles found in almost all eukaryotes and
involved in various aspects of cellular life, with a primary role in energy production. The …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Assessing mitochondrial dysfunction requires definition of the dysfunction to be investigated.
Usually, it is the ability of the mitochondria to make ATP appropriately in response to energy …

Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for
assessing mitochondrial function, particularly in the context of cell fate determination in …

Stroke and circulatory arrest cause interferences in blood flow to the brain that result in
considerable tissue damage. The primary method to reduce or prevent neurologic damage …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether
derived from the diet or from fermentation in the colon, has been implicated in a range of …

The molecular origin of standard metabolic rate and thermogenesis in mammals is
examined. It is pointed out that there are important differences and distinctions between the …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …