Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

Secretome, also known as conditioned medium, is a secreted molecule from mesenchymal
stem cells (MSCs) that has a variety of biological activities that can be used in various …

Burns are caused by several mechanisms including flame, scald, chemical, electrical, and
ionizing and non-ionizing radiation. Approximately half a million burn cases are registered …

For almost two decades, cell-based therapies have been tested in modern regenerative
medicine to either replace or regenerate human cells, tissues, or organs and restore normal …

Although the application of stem cells to chronic wounds emerged as a candidate therapy in
the previous century, the mechanism of action remains unclear. Recent evidence has …

Skin ageing is predominantly caused by either intrinsic or extrinsic factors, leading to
undesirable skin features. Advancements in both molecular and cellular fields have created …

Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern
cutaneous regenerative medicine. Based on advancements in the relevant scientific …

Secretome-based therapies have the potential to become the next generation of viable
therapeutic wound repair treatments. However, precise strategies aimed to refine and …

Animal models provide a way to investigate scar therapies in a controlled environment. It is
necessary to produce uniform, reproducible scars with high anatomic and biologic similarity …

Secretomes from various cell sources exert strong regenerative activities on numerous
organs, including the skin. Although secretomes consist of many diverse components, a …