Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

Recurrent seizures in epilepsy may lead to progressive neuronal damage, which can
diminish health-related quality of life. Evaluation and control of pathological processes in the …

Acute kidney injury (AKI) is a collection of clinical syndromes with persistent increases in
morbidity and mortality rates. Hyperglycemia is a risk factor for AKI development. Renin …

Background The objective of this study was to examine the correlation between serum
Klotho protein concentration and postmenopausal hypertension. Methods A cross-sectional …

Background: Klotho is widely recognized as a protein that combats aging and possesses
antioxidative characteristics, which have been implicated in the pathophysiology of …

Purpose Exposure to perfluoroalkyl and polyfluoroalkyl substances causes oxidative stress,
which is strongly associated with adverse health effects. Klotho protein plays an anti-aging …

Highlights•Kidney diseases cause high morbidity and mortality worldwide.•Target-specific
therapies are missing for many kidney diseases.•Novel druggable targets for kidney disease …

The prevalence of sleep disorders has been reported from 1.6% to 56.0%, worldwide. Sleep
deprivation causes cardiovascular diseases (CVDs) including atherosclerosis, vascular …

Сhronic kidney Disease (CKD) is the cause of both morbidity and mortality worldwide. In
Ukraine, 12% of the population is diagnosed with CKD. Significantly worsen the quality of …

Klotho is a renoprotective factor that is at the forefront of research as a potential therapeutic
agent and biomarker of acute kidney injury (AKI). Endoplasmic reticulum (ER) stress and …