Intrahost evolution of the gut microbiota
HC Barreto, I Gordo - Nature Reviews Microbiology, 2023 - nature.com
A massive number of microorganisms, belonging to different species, continuously divide
inside the guts of animals and humans. The large size of these communities and their rapid …
inside the guts of animals and humans. The large size of these communities and their rapid …
Pneumococcal within-host diversity during colonization, transmission and treatment
Characterizing the genetic diversity of pathogens within the host promises to greatly improve
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
surveillance and reconstruction of transmission chains. For bacteria, it also informs our …
The pneumococcal social network
Gram-positive bacteria employ an array of secreted peptides to control population-level
behaviors in response to environmental cues. We review mechanistic and functional …
behaviors in response to environmental cues. We review mechanistic and functional …
Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections
During severe infections, Staphylococcus aureus moves from its colonising sites to blood
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
and tissues and is exposed to new selective pressures, thus, potentially driving adaptive …
Genome wide association study of Escherichia coli bloodstream infection isolates identifies genetic determinants for the portal of entry but not fatal outcome
E Denamur, B Condamine, M Esposito-Farese… - PLoS …, 2022 - journals.plos.org
Escherichia coli is an important cause of bloodstream infections (BSI), which is of concern
given its high mortality and increasing worldwide prevalence. Finding bacterial genetic …
given its high mortality and increasing worldwide prevalence. Finding bacterial genetic …
[HTML][HTML] BlpC-mediated selfish program leads to rapid loss of Streptococcus pneumoniae clonal diversity during infection
SD Aggarwal, JA Lees, NT Jacobs, GCW Bee… - Cell host & …, 2023 - cell.com
Successful colonization of a host requires bacterial adaptation through genetic and
population changes that are incompletely defined. Using chromosomal barcoding and high …
population changes that are incompletely defined. Using chromosomal barcoding and high …
Deep longitudinal lower respiratory tract microbiome profiling reveals genome-resolved functional and evolutionary dynamics in critical illness
The lower respiratory tract (LRT) microbiome impacts human health, especially among
critically ill patients. However, comprehensive characterizations of the LRT microbiome …
critically ill patients. However, comprehensive characterizations of the LRT microbiome …
[HTML][HTML] Ultrastructural, metabolic and genetic characteristics of determinants facilitating the acquisition of macrolide resistance by Streptococcus pneumoniae
Aims To investigate the molecular events associated with acquiring macrolide resistance
genes [mefE/mel (Mega) or ermB] in Streptococcus pneumoniae (Spn) during …
genes [mefE/mel (Mega) or ermB] in Streptococcus pneumoniae (Spn) during …
[HTML][HTML] Insights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation
MMH Abdelbary, M Hatting, A Dahlhausen… - International Journal of …, 2024 - mdpi.com
The oral–gut axis is a complex system linking the oral cavity and gastrointestinal tract,
impacting host health and microbial composition. This study investigates genetic changes …
impacting host health and microbial composition. This study investigates genetic changes …
Pneumococcal colonization and virulence factors identified via experimental evolution in infection models
Streptococcus pneumoniae is a commensal of the human nasopharynx and a major cause
of respiratory and invasive disease. We examined adaptation and evolution of …
of respiratory and invasive disease. We examined adaptation and evolution of …