Infections caused by metallo-β-lactamase (MBL)-producing Enterobacterales and
Pseudomonas are increasingly reported worldwide and are usually associated with high …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …

Carbapenem-resistant Enterobacterales (CRE) are a growing threat to human health
worldwide. CRE often carry multiple resistance genes that limit treatment options and …

ABSTRACT Imipenem (IMI)/cilastatin/relebactam (REL)(I/R) is a novel β-lactam/β-lactamase
inhibitor combination with expanded microbiologic activity against carbapenem-resistant …

Klebsiella pneumoniae as a main opportunistic pathogen is a common cause of health-care-
associated bacterial infections, which has shown high levels of drug resistance specifically …

Gram-negative bacterial resistance to antimicrobials has had an exponential increase at a
global level during the last decades and represent an everyday challenge, especially for the …

Polymyxins are commonly used as the last resort for the treatment of MDR Acinetobacter
baumannii and Klebsiella pneumoniae nosocomial infections; however, apart from the …

Antimicrobial resistance represents a serious threat for global health, causing an
unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in …

Severe infections caused by DTR-GNB pose a formidable challenge for healthcare
providers and represent a growing global health issue. The proper administration and …

ABSTRACT Introduction Metallo-beta-lactamases (MBLs) are responsible for resistance to
almost all beta-lactam antibiotics. Found predominantly in Gram-negative bacteria, they …