Highlights in resistance mechanism pathways for combination therapy
Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years.
Although the mechanisms of action and signaling pathways affected by most treatments with …
Although the mechanisms of action and signaling pathways affected by most treatments with …
Advantages of the combinatorial molecular targeted therapy of head and neck cancer—A step before anakoinosis-based personalized treatment
R Kleszcz - Cancers, 2023 - mdpi.com
Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is a major threat to
public health around the world. Its occurrence is linked to genetic events and environmental …
public health around the world. Its occurrence is linked to genetic events and environmental …
The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation
D Yu, X Liu, G Han, Y Liu, X Zhao, D Wang… - Cell Communication and …, 2019 - Springer
Background Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-
L1) has been documented in several cancers and contributes to the evasion of the host …
L1) has been documented in several cancers and contributes to the evasion of the host …
ABCB1 and ABCG2 overexpression mediates resistance to the phosphatidylinositol 3-kinase inhibitor HS-173 in cancer cell lines
CP Wu, CY Hung, YJ Hsieh, M Murakami, YH Huang… - Cells, 2023 - mdpi.com
Constitutive activation of the phosphoinositide-3-kinase (PI3K)/Akt signaling pathway is
crucial for tumor growth and progression. As such, this pathway has been an enticing target …
crucial for tumor growth and progression. As such, this pathway has been an enticing target …
PI3k inhibitors (BKM120 and BYL719) as radiosensitizers for head and neck squamous cell carcinoma during radiotherapy
FC Chuang, CC Wang, JH Chen, TZ Hwang, SA Yeh… - PLoS …, 2021 - journals.plos.org
Approximately 500,000 new cases of head and neck squamous cell carcinoma (HNSCC)
are reported annually. Radiation therapy is an important treatment for oral squamous cell …
are reported annually. Radiation therapy is an important treatment for oral squamous cell …
Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene
Abstract Background Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and
aggressive skull base tumor with poor survival and limited treatment options. To date …
aggressive skull base tumor with poor survival and limited treatment options. To date …
Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma
Background Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease
with poor survival. Although epidermal growth factor receptor (EGFR)‐targeting antibody …
with poor survival. Although epidermal growth factor receptor (EGFR)‐targeting antibody …
IGF2 mediates resistance to isoform-selective-inhibitors of the PI3K in HPV positive head and neck cancer
Simple Summary In the current study, we delineate the molecular mechanisms of acquisition
of resistance to two isoform-selective inhibitors of PI3K (isiPI3K), alpelisib and taselisib, in …
of resistance to two isoform-selective inhibitors of PI3K (isiPI3K), alpelisib and taselisib, in …
Multi-kinase compensation rescues EGFR knockout in a cell line model of head and neck squamous cell carcinoma
Background Head and neck squamous cell carcinoma (HNSCC) is a debilitating disease
with poor survival rates. While the epidermal growth factor receptor (EGFR)-targeting …
with poor survival rates. While the epidermal growth factor receptor (EGFR)-targeting …
[HTML][HTML] Dacomitinib and gedatolisib in combination with fractionated radiation in head and neck cancer
Abstract Background and Purpose There has been little success targeting individual genes
in combination with radiation in head and neck cancer. In this study we investigated whether …
in combination with radiation in head and neck cancer. In this study we investigated whether …