Mitochondrial unfolded protein response (UPR mt) is a mitochondria stress response, which
the transcriptional activation programs of mitochondrial chaperone proteins and proteases …

Mitochondria are sensitive to numerous environmental stresses, which can lead to activation
of mitochondrial stress responses (MSRs). Of particular recent interest has been the …

Age-related loss of skeletal muscle mass and contractile dysfunction, or sarcopenia, reduces
independence and quality of life in the elderly and leads to increased risk of comorbidities …

Objective A decline in mitochondrial function and biogenesis as well as increased reactive
oxygen species (ROS) are important determinants of aging. With advancing age, there is a …

Cytochrome c oxidase (COX) is the terminal enzyme of the electron transport chain and
catalyzes the transfer of electrons from cytochrome c to oxygen. COX consists of 14 subunits …

Mitochondrial dysfunction is a key pathological event in many diseases. Its role in energy
production, calcium homeostasis, apoptosis regulation, and reactive oxygen species (ROS) …

Many Amyotrophic Lateral Sclerosis (ALS) patients experience hypermetabolism, or an
increase in measured vs. calculated metabolic rate. The cause of hypermetabolism and the …

Abstract Structure and integrity of the mitochondrial network play important roles in many
cellular processes. Loss of integrity can lead to the activation of a variety of signalling …

The mitochondrial unfolded protein response (UPRmt) can repair and remove misfolded or
unfolded proteins in mitochondria and enhance mitochondrial protein homeostasis …

Mitochondria are established essential regulators of cellular function and metabolism.
Mitochondria regulate redox homeostasis, maintain energy (ATP) production through …