Oxidative stress and abdominal aortic aneurysm: potential treatment targets

TI Emeto, JV Moxon, M Au, J Golledge - Clinical science, 2016 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key
mechanism implicated in AAA pathogenesis is inflammation and the associated production …

The abdominal aortic aneurysm and intraluminal thrombus: current concepts of development and treatment

A Piechota-Polanczyk, A Jozkowicz… - Frontiers in …, 2015 - frontiersin.org
The pathogenesis of the abdominal aortic aneurysm (AAA) shows several hallmarks of
atherosclerotic and atherothrombotic disease, but comprises an additional, predominant …

[HTML][HTML] Abdominal aortic aneurysm genetic associations: mostly false? A systematic review and meta-analysis

DT Bradley, SA Badger, M McFarland… - European Journal of …, 2016 - Elsevier
Objective/Background Many associations between abdominal aortic aneurysm (AAA) and
genetic polymorphisms have been reported. It is unclear which are genuine and which may …

Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease

R Pechlaner, P Willeit, M Summerer… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—The enzyme heme oxygenase-1 (HO-1) exerts cytoprotective effects in response
to various cellular stressors. A variable number tandem repeat polymorphism in the HO-1 …

A dual role of heme oxygenase-1 in angiotensin II-induced abdominal aortic aneurysm in the normolipidemic mice

A Kopacz, D Klóska, E Werner, K Hajduk… - Cells, 2021 - mdpi.com
Abdominal aortic aneurysm (AAA) bears a high risk of rupture and sudden death of the
patient. The pathogenic mechanisms of AAA remain elusive, and surgical intervention …

[HTML][HTML] Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice

YC Ho, ML Wu, PY Gung, CH Chen, CC Kuo, SF Yet - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abdominal aortic aneurysm (AAA) is a chronic but often fatal disease in elderly population.
Heme oxygenase-1 (HO-1) is a stress response protein with antioxidative and anti …

Association of HMOX1 and NQO1 Polymorphisms with Metabolic Syndrome Components

A Martínez-Hernández, EJ Córdova… - PLoS …, 2015 - journals.plos.org
Metabolic syndrome (MetS) is among the most important public health problems worldwide,
and is recognized as a major risk factor for various illnesses, including type 2 diabetes …

[HTML][HTML] Heme oxygenase-1 gene promoter polymorphisms are associated with coronary heart disease and restenosis after percutaneous coronary intervention: a …

MM Zhang, YY Zheng, Y Gao, JZ Zhang, F Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Numerous published studies have suggested that there is association between heme
oxygenase-1 (HO-1) gene polymorphisms and coronary heart disease (CHD) or restenosis …

Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells

D Klóska, A Kopacz, A Piechota-Polańczyk… - Archives of biochemistry …, 2019 - Elsevier
Endothelial dysfunction accompanied by the loss of endothelial cell phenotype plays an
essential role in cardiovascular diseases. Here, we report that knockdown of biliverdin …

The role of statins in the activation of heme oxygenase-1 in cardiovascular diseases

A Piechota-Polanczyk, A Jozkowicz - Current Drug Targets, 2017 - ingentaconnect.com
Cardiovascular diseases (CVD) are associated with the dysfunction of endothelium that
regulates the contractile state of vascular walls and cellular composition. Recent large …