Spinal cord injury (SCI) affects millions of individuals worldwide. Currently, there is no cure,
and treatment options to promote neural recovery are limited. An innovative approach to …

The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …

Repairing injured tissues/organs is one of the major challenges for the maintenance of
proper organ function in adulthood. In mammals, the central nervous system including the …

Salamanders are tetrapod models to study brain organization and regeneration; however,
the identity and evolutionary conservation of brain cell types are largely unknown. We …

Turbidity and opaqueness are inherent properties of tissues that limit the capacity to acquire
microscopic images through large tissues. Creating a uniform refractive index, known as …

Connective tissues—skeleton, dermis, pericytes, fascia—are a key cell source for
regenerating the patterned skeleton during axolotl appendage regeneration. This complexity …

The adult spinal cord stem cell potential resides within the ependymal cell population and
declines with age. Ependymal cells are, however, heterogeneous, and the biological …

Salamanders exhibit extensive regenerative capacities and serve as a unique model in
regeneration research. However, due to the lack of targeted gene knockin approaches, it …

Identifying key molecules that launch regeneration has been a long-sought goal. Multiple
regenerative animals show an initial wound-associated proliferative response that transits …

Large-scale regeneration in the adult central nervous system is a unique capacity of
salamanders among tetrapods. Salamanders can replace neuronal populations, repair …