MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a non-
cell autonomous motor neuron loss. While it is generally believed that the disease onset …

Genome damage and their defective repair have been etiologically linked to degenerating
neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the …

Mammalian telomeres consist of (TTAGGG) n repeats. Transcription of the C-rich strand
generates a G-rich RNA, termed TERRA, containing G-quadruplex structures. Recent …

Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …

Genome damage and defective repair are etiologically linked to neurodegeneration.
However, the specific mechanisms involved remain enigmatic. Here, we identify defects in …

Biomolecular condensation arising through phase transitions has emerged as an essential
organizational strategy that governs many aspects of cell biology. In particular, the role of …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …

FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear
ribonucleoprotein family, have gained significant attention in the field of neurodegenerative …

Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of upper and lower
motor neurons (MNs) leading to paralysis and, ultimately, death by respiratory failure 3–5 …