Regulation of the renal NaCl cotransporter and its role in potassium homeostasis

EJ Hoorn, M Gritter, CA Cuevas… - Physiological …, 2020 - journals.physiology.org
Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Potassium homeostasis: the knowns, the unknowns, and the health benefits

AA McDonough, JH Youn - Physiology, 2017 - journals.physiology.org
Potassium homeostasis has a very high priority because of its importance for membrane
potential. Although extracellular K+ is only 2% of total body K+, our physiology was …

Potassium homeostasis: sensors, mediators, and targets

AA McDonough, RA Fenton - Pflügers Archiv-European Journal of …, 2022 - Springer
Transmembrane potassium (K) gradients are key determinants of membrane potential that
can modulate action potentials, control muscle contractility, and influence ion channel and …

Dietary potassium and the kidney: lifesaving physiology

KY Wei, M Gritter, L Vogt, MH De Borst… - Clinical Kidney …, 2020 - academic.oup.com
Potassium often has a negative connotation in Nephrology as patients with chronic kidney
disease (CKD) are prone to develop hyperkalaemia. Approaches to the management of …

[HTML][HTML] Potassium homeostasis–Physiology and pharmacology in a clinical context

R Kettritz, J Loffing - Pharmacology & Therapeutics, 2023 - Elsevier
Membrane voltage controls the function of excitable cells and is mainly a consequence of
the ratio between the extra-and intracellular potassium concentration. Potassium …

Role of Dietary K+ in Natriuresis, Blood Pressure Reduction, Cardiovascular Protection, and Renoprotection

M Gritter, JI Rotmans, EJ Hoorn - Hypertension, 2019 - Am Heart Assoc
16 Hypertension January 2019 pNCC in urinary extracellular vesicles reflecting higher
pNCC in the kidney. 32 Physiologically, activation of NCC by low K+ conditions likely helps …

Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice

GR Crislip, LG Douma, SH Masten… - American Journal …, 2020 - journals.physiology.org
The renal circadian clock has a major influence on the function of the kidney. Aryl
hydrocarbon receptor nuclear translocator-like protein 1 [ARNTL; also known as brain and …

A critical review of bioactive food components, and of their functional mechanisms, biological effects and health outcomes

R Perez-Gregorio… - Current Pharmaceutical …, 2017 - ingentaconnect.com
Background: Eating behaviours are closely related to some medical conditions potentially
leading to death such as cancer, cardiovascular disease and diabetes. Healthy eating …

[HTML][HTML] Potassium acts through mTOR to regulate its own secretion

MV Sørensen, B Saha, IS Jensen, P Wu, N Ayasse… - JCI insight, 2019 - ncbi.nlm.nih.gov
Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in
mammals. In the K+-secreting principal cells of the distal nephron, electrogenic Na+ …

Potassium activates mTORC2-dependent SGK1 phosphorylation to stimulate epithelial sodium channel: role in rapid renal responses to dietary potassium

B Saha, W Shabbir, E Takagi, XP Duan… - Journal of the …, 2023 - journals.lww.com
Background Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+] …