Antidepressants' effects on testosterone and estrogens: What do we know?

P Pavlidi, N Kokras, C Dalla - European journal of pharmacology, 2021 - Elsevier
Various antidepressants are commonly used to treat depression and anxiety disorders, and
sex differences have been identified in their efficacy and side effects. Steroids, such as …

Effect of antidepressant medications on semen parameters and male fertility

LA Beeder, MK Samplaski - International Journal of Urology, 2020 - Wiley Online Library
Antidepressant medications are commonly used in males of reproductive age for long‐term
treatment of depression, as well as other disorders. Although antidepressants are known to …

Application of the comet assay for the evaluation of DNA damage in mature sperm

G Gajski, S Ravlić, R Godschalk, A Collins… - … Research/Reviews in …, 2021 - Elsevier
DNA integrity is considered an important parameter of semen quality and is of significant
value as a predictor of male fertility. Currently, there are several methods that can assess …

Concentrated ambient PM2. 5 exposure affects mice sperm quality and testosterone biosynthesis

Y Yang, T Yang, S Liu, Z Cao, Y Zhao, X Su, Z Liao… - PeerJ, 2019 - peerj.com
Background Studies suggested that PM2. 5 exposure could lead to adverse reproductive
effects on male animals. However, the underlying mechanism is still not clear. Besides …

Olanzapine induced reproductive toxicity in male rats

CM Ardıç, S Ilgın, M Baysal, AB Karaduman, V Kılıç… - Scientific Reports, 2021 - nature.com
Although it is reported that olanzapine (OLZ), which is an atypical antipsychotic drug, causes
sexual dysfunction in men, it is noteworthy that there is not any study evaluating the toxic …

The effect of SSRIs on Semen quality: A systematic review and meta-analysis

J Xu, K He, Y Zhou, L Zhao, Y Lin, Z Huang… - Frontiers in …, 2022 - frontiersin.org
Selective serotonin reuptake inhibitors (SSRIs) are widely used for a variety of diseases, and
their impact on semen quality is unclear. We performed a systematic search in PubMed and …

Effects of clinical medications on male fertility and prospects for stem cell therapy

P Mo, Z Zhao, X Ke, Y Fan, C Li - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
An increasing number of men require long-term drug therapy for various diseases. However,
the effects of long-term drug therapy on male fertility are often not well evaluated in clinical …

Harmful consequences of proton pump inhibitors on male fertility: an evidence from subchronic toxicity study of esomeprazole and lansoprazole in wistar rats

N Mumtaz, MF Akhtar, A Saleem… - International journal of …, 2022 - Wiley Online Library
Proton pump inhibitors (PPIs) are frequently prescribed as gastric acid‐suppressing agents.
Nevertheless, there is limited evidence supporting the risk of detrimental effects of PPIs on …

The protective role of melatonin in citalopram-induced reproductive toxicity via modulating nitro-oxidative stress and apoptosis in male mice

M Moradi, MA Hashemian, E Douhandeh… - Reproductive …, 2023 - Elsevier
Citalopram is the most potent selective serotonin reuptake inhibitor, commonly prescribed as
an antidepressant, which can cause sexual dysfunction. Melatonin is a natural, highly …

Utility of vitamin C in ameliorating citalopram‐induced testicular toxicity via modulating nitro‐oxidative stress and apoptosis in mice

M Moradi, MA Hashemian, M Fathi… - … of Biochemical and …, 2024 - Wiley Online Library
There is a growing concern that antidepressant drugs impair sexual function and adversely
impact spermatogenesis and male fertility. Vitamin C is a natural antioxidant that plays a vital …