Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Obesity, diabetes mellitus, hypertension and cardiovascular disease are risk factors for
chronic kidney disease (CKD) and kidney failure. Chronic, low-grade inflammation is …

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …

Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Type 2 diabetes mellitus is a pathology of heterogeneous etiology characterized by
hyperglycemia resulting from lack of insulin action, insulin secretion, or both, and the …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …