Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy
of the viral RNA genome is stably incorporated into a host cell chromosome. Integrase is the …

The integration of a DNA copy of the viral RNA genome into host chromatin is the defining
step of retroviral replication. This enzymatic process is catalyzed by the virus-encoded …

Despite our ability to suppress HIV-1 replication indefinitely in people on optimal combined
antiretroviral therapy (cART), HIV-1 persists as a stably integrated and replication-competent …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human
chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) …

Human immunodeficiency virus type 1 (HIV-1) displays the unique ability to infect
nondividing cells. The capsid of HIV-1 is the viral determinant for viral nuclear import. To …

HIV-1 persists lifelong in memory cells of the immune system as latent provirus that
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …

Persistence of latent, replication-competent Human Immunodeficiency Virus type 1 (HIV-1)
provirus is the main impediment towards a cure for HIV/AIDS (Acquired Immune Deficiency …

Integration is central to HIV-1 replication and helps mold the reservoir of cells that persists in
AIDS patients. HIV-1 interacts with specific cellular factors to target integration to interior …