The gut, its microbiome, and hypertension

EM Richards, CJ Pepine, MK Raizada… - Current hypertension …, 2017 - Springer
Abstract Purpose of the Review Evidence is rapidly accumulating implicating gut dysbiosis
in hypertension (HTN). However, we are far from understanding whether this is a cause or …

microRNA in cardiovascular aging and age-related cardiovascular diseases

C de Lucia, K Komici, G Borghetti… - Frontiers in …, 2017 - frontiersin.org
Over the last decades, life expectancy has significantly increased although several chronic
diseases persist in the population, with aging as the leading risk factor. Despite …

Mean platelet volume/platelet count ratio and dipper/non-dipper hypertensive patients

SG Nurkoç, T Yakışan - Angiology, 2024 - journals.sagepub.com
There is an interaction between mean platelet volume (MPV), platelet count (PC),
inflammation, and platelet reactivity. The present study evaluated the relationship between …

MicroRNAs regulating renin–angiotensin–aldosterone system, sympathetic nervous system and left ventricular hypertrophy in systemic arterial hypertension

AC Improta-Caria, MG Aras, L Nascimento… - biomolecules, 2021 - mdpi.com
MicroRNAs are small non-coding RNAs that regulate gene and protein expression.
MicroRNAs also regulate several cellular processes such as proliferation, differentiation, cell …

The circulating level of miR-122 is a potential risk factor for endothelial dysfunction in young patients with essential hypertension

HG Zhang, QJ Zhang, BW Li, LH Li, XH Song… - Hypertension …, 2020 - nature.com
MicroRNAs are key molecules involved in the regulation of endothelial function. They are
important risk factors and biomarkers for the development of hypertension related to …

Future treatments in hypertension: Can we meet the unmet needs of patients?

M Kanbay, S Copur, C Tanriover, D Ucku… - European Journal of …, 2023 - Elsevier
The prevalence of arterial hypertension is approximately 47% in the United States and 55%
in Europe. Multiple different medical therapies are used to treat hypertension including …

Genetic and epigenetic factors of arterial hypertension: a bibliometric-and in-silico-based analyses

RZ Karabaeva, TA Vochshenkova, A Zare… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Arterial hypertension (AH) is a pervasive global health concern with
multifaceted origins encompassing both genetic and environmental components. Previous …

Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension

J Liao, Y Zhang, Y Wu, F Zeng, L Shi - Life sciences, 2018 - Elsevier
Aims This study investigated whether long-term exercise can influence vascular smooth
muscle cells (VSMCs) phenotypic switching in mesenteric arteries of hypertensive rats, with …

PRMT1 modulates processing of asthma-related primary MicroRNAs (Pri-miRNAs) into mature miRNAs in lung epithelial cells

W Zhai, H Sun, Z Li, L Li, A Jin, Y Li, J Chen… - The Journal of …, 2021 - journals.aai.org
Abstract Protein arginine methyltransferase-1 (PRMT1) is an important epigenetic regulator
of cell function and contributes to inflammation and remodeling in asthma in a cell type …

Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

M Elgazzaz, E Lazartigues - Clinical Science, 2021 - portlandpress.com
Cardiometabolic diseases (CMDs) are among the most prevalent and the highest mortality
diseases. Single disease etiology such as gene mutation, polymorphisms, or environmental …