Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological
and pathological processes including cancer. However, despite its importance the role of …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

MicroRNA (miRNA) inhibition is a promising therapeutic strategy in several disease
indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets …

Summary Background Anti-programmed death-1 (PD-1) treatment for advanced non-small-
cell lung cancer (NSCLC) has improved the survival of patients. However, a substantial …

Background Epigenetic clocks use DNA methylation (DNAm) levels of specific sets of CpG
dinucleotides to accurately predict individual chronological age. A popular application of …

Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2,
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

Abstract Hormone-receptor positive (HR+) breast cancer (BC)(including the luminal A and
the luminal B subtypes) is the most common type of tumor in women diagnosed with early …

There is an exponentially growing interest in targeting immune checkpoint molecules in
breast cancer (BC), particularly in the triple-negative subtype where unmet treatment needs …