Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for
new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for …

Abstract Development of taxane resistance has become clinically very important issue. The
molecular mechanisms underlying the resistance are still unclear. To address this issue, we …

Increasingly, the effectiveness of adjuvant chemotherapy agents for breast cancer has been
related to changes in the genomic profile of tumors. We investigated correspondence …

Previous studies have demonstrated that breast cancer cells deploy a myriad array of
strategies to thwart the activity of anticancer drugs like docetaxel (DTX), including acquired …

Resistance to adjuvant systemic treatment, including taxanes (docetaxel and paclitaxel) is a
major clinical problem for breast cancer patients. lncRNAs (long non-coding RNAs) are non …

Rationally designed combination nano-therapy approaches have emerged as a promising
strategy for resistant breast cancer treatment. This research reports the combination of …

Background Recent studies have demonstrated that autophagy plays a critical role in
reducing the drug sensitivity of docetaxel (DTX) therapy. Disulfiram (DSF) has exhibited …

Docetaxel (DTX) was the first chemotherapeutic agent to demonstrate significant efficacy in
the treatment of men with metastatic castration-resistant prostate cancer. However, response …