Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds
G Chen, F Wang, D Trachootham, P Huang - Mitochondrion, 2010 - Elsevier
Mitochondria play essential roles in cellular metabolism, redox homeostasis, and regulation
of cell death. Emerging evidences suggest that cancer cells exhibit various degrees of …
of cell death. Emerging evidences suggest that cancer cells exhibit various degrees of …
miR-17-5p downregulation contributes to paclitaxel resistance of lung cancer cells through altering beclin1 expression
A Chatterjee, D Chattopadhyay, G Chakrabarti - PloS one, 2014 - journals.plos.org
Non-small-cell lung cancer (NSCLC) is one of the most leading causes of cancer-related
deaths worldwide. Paclitaxel based combination therapies have long been used as a …
deaths worldwide. Paclitaxel based combination therapies have long been used as a …
Unprecedented inhibition of tubulin polymerization directed by gold nanoparticles inducing cell cycle arrest and apoptosis
The effect of gold nanoparticles (AuNPs) on the polymerization of tubulin has not been
examined till now. We report that interaction of weakly protected AuNPs with microtubules …
examined till now. We report that interaction of weakly protected AuNPs with microtubules …
Apigenin shows synergistic anticancer activity with curcumin by binding at different sites of tubulin
Apigenin, a natural flavone, present in many plants sources, induced apoptosis and cell
death in lung epithelium cancer (A549) cells with an IC50 value of 93.7±3.7 μM for 48 h …
death in lung epithelium cancer (A549) cells with an IC50 value of 93.7±3.7 μM for 48 h …
Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells
D Choudhury, A Das, A Bhattacharya… - Food and chemical …, 2010 - Elsevier
Ginger has a long history of use as traditional medicine for varied human disease. Our
present study has shown that the aqueous extract of ginger (GAE) interacts directly with …
present study has shown that the aqueous extract of ginger (GAE) interacts directly with …
A new clerodane furano diterpene glycoside from Tinospora cordifolia triggers autophagy and apoptosis in HCT-116 colon cancer cells
N Sharma, A Kumar, PR Sharma, A Qayum… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance Tinospora cordifolia is a miraculous ayurvedic herb used
in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis …
in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis …
Heavy water (D2O) induces autophagy-dependent apoptotic cell death in non-small cell lung cancer A549 cells by generating reactive oxygen species (ROS) upon …
Abstract Objective Deuterium oxide (D 2 O) or heavy water is known to have diverse
biological activities and have a few therapeutic applications due to its limited toxicity to …
biological activities and have a few therapeutic applications due to its limited toxicity to …
The microtubule depolymerizing agent naphthazarin induces both apoptosis and autophagy in A549 lung cancer cells
BR Acharya, S Bhattacharyya, D Choudhury… - Apoptosis, 2011 - Springer
Abstract Naphthazarin (DHNQ, 5, 8-dihydroxy-l, 4-naphthoquinone) is a naturally available
1, 4-naphthoquinone derivatives. In this study, we focused on elucidating the cytotoxic …
1, 4-naphthoquinone derivatives. In this study, we focused on elucidating the cytotoxic …
Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells
C Zhang, L Yang, X Wang, J Wang, C Yang, L Kong - Cancer letters, 2013 - Elsevier
Calyxin Y has been recently isolated from Alpinia katsumadai which has a folk use as an
anti-tumor medicine. Calyxin Y induced caspase-dependent cell death in NCI-H460 cells …
anti-tumor medicine. Calyxin Y induced caspase-dependent cell death in NCI-H460 cells …