Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

Notch 1 through 4 are transmembrane receptors that play a pivotal role in cell differentiation
and function; this review addresses the role of Notch signaling in osteoclastogenesis and …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most
common cause of cancer-related mortality among men in the developed world …

Purpose: To investigate the efficacy and mechanisms of Notch signaling inhibition as an
adjuvant to docetaxel in castration-resistant prostate cancer (CRPC) using a γ-secretase …

Notch signaling is a key regulator of vascular smooth muscle cell (VSMC) phenotypes,
including differentiation, proliferation, and cell survival. However, the exact contribution of …

The Notch signaling pathway is a fundamental signaling mechanism operating in most, if not
all, multicellular organisms and in most cell types in the body. Like other" ivy league" …

PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which
are tightly regulated in normal tissues, but upregulated in many types of human …

Tumorigenesis is a multistep process involving co-operation between several deregulated
oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk …

Our previous study demonstrated a close relationship between the NOTCH signaling
pathway and salivary adenoid cystic carcinoma (SACC). Its receptor gene, NOTCH1, and its …