The gene encoding the receptor-tyrosine kinase RET was first discovered more than three
decades ago, and activating RET rearrangements and mutations have since been identified …

Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …

A hallmark of cancer is the ability of tumor cells to avoid immune destruction. Activated
immune cells in tumor microenvironment (TME) secrete proinflammatory cytokines and …

Abstract (C–X–C motif) ligand (CXCL) 10 (CXCL10) belongs to the ELR− CXC subfamily
chemokine. CXCL10 exerts its function through binding to chemokine (C–X–C motif) …

Follicular thyroid carcinoma (FTC) and benign follicular adenoma (FA) are indistinguishable
by preoperative diagnosis due to their similar histological features. Here we report the first …

microRNAs (miRNAs) are a new class of non-protein-coding, endogenous, small RNAs.
They are important regulatory molecules in animals and plants. miRNA regulates gene …

Since the molecular revolution of the 1980s, knowledge of the aetiology of cancer has
increased considerably, which has led to the discovery and development of targeted …

Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

Apart from alterations in the RET/PTC-RAS-BRAF pathway, comparatively little is known
about the genetics of papillary thyroid carcinoma (PTC). We show that numerous microRNAs …

In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …