The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …

Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological
samples in near-native environments. Thus, cryo-ET has become the method of choice to …

The actin cytoskeleton impacts practically every function of a eukaryotic cell. Historically, the
best-characterized cytoskeletal activities are in cell morphogenesis, motility, and division …

We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3
actin nucleator complex, in two unrelated patients presenting with recurrent and severe …

The Arp2/3 complex drives the formation of branched actin networks that are essential for
many cellular processes. In humans, the ARPC5 subunit of the Arp2/3 complex is encoded …

CD4 T cell activation induces nuclear and cytoplasmic actin polymerization via the Arp2/3
complex to activate cytokine expression and strengthen T cell receptor (TCR) signaling …

The molecular mechanisms underlying cell migration remain incompletely understood.
Here, we show that knock-out cells for NHSL3, the most recently identified member of the …

The dynamic turnover of actin filaments drives the morphogenesis and migration of all
eukaryotic cells. This review summarizes recent insights into the molecular mechanisms of …

The inhibitors, CK-666 and CK-869, are widely used to probe the function of Arp2/3 complex
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …

Cryo-electron tomography (cryo-ET) has begun to provide intricate views of cellular
architecture at unprecedented resolutions. Considerable efforts are being made to further …