Nitrones have been extensively used for the detection of transient free radicals using
electron paramagnetic resonance. Since the mid-80's, nitrones have also been widely used …

Due to the role of butyrylcholinesterase (BChE) in acetylcholine hydrolysis in the late stages
of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been …

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting
cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and …

Despite the controversial outcomes of clinical trials executed so far, the prevention of β-
amyloid (Aβ) deposition and neurotoxicity by small molecule inhibitors of Aβ aggregation …

Dantrolene, a drug used for the management of malignant hyperthermia, had been recently
evaluated for prospective repurposing as multitarget agent for neurodegenerative …

Mitochondrial-dependent apoptosis plays an important role in the degeneration of
dopaminergic neurons in Parkinson's disease (PD). Methyl-4-phenyl-1, 2, 3, 6-tetra …

The enantiomer separation of a number of racemic 7‐[(1‐alkylpiperidin‐3‐yl) methoxy]
coumarin derivatives, some of which show outstanding in vitro multitarget neuroprotective …

The regioselective functionalization of four-and six-membered cyclic sulfones was
investigated using a lithiation/electrophile trapping strategy. The protocol features an …

Translocator protein 18-kDa (TSPO) is a versatile mitochondrial target for molecular imaging
and therapy. Moreover, selective TSPO ligands have been widely investigated for diagnostic …

Nature-inspired, bridged polycyclic molecules share low similarity with currently available
drugs, containing preferentially planar and/or achiral moieties. This “Escape from Flatland” …