Excitation and inhibition imbalance in Rett syndrome

W Li - Frontiers in Neuroscience, 2022 - frontiersin.org
A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

Inhibitory synaptic influences on developmental motor disorders

MJ Fogarty - International Journal of Molecular Sciences, 2023 - mdpi.com
During development, GABA and glycine play major trophic and synaptic roles in the
establishment of the neuromotor system. In this review, we summarise the formation …

Breathing abnormalities during sleep and wakefulness in Rett syndrome: clinical relevance and paradoxical relationship with circulating pro-oxidant markers

S Leoncini, C Signorini, L Boasiako… - Frontiers in …, 2022 - frontiersin.org
Background Breathing abnormalities are common in Rett syndrome (RTT), a pervasive
neurodevelopmental disorder almost exclusively affecting females. RTT is linked to …

Potamogeton perfoliatus L. Extract Attenuates Neuroinflammation and Neuropathic Pain in Sciatic Nerve Chronic Constriction Injury-Induced Peripheral Neuropathy …

MF Mahmoud, S Rezq, AE Alsemeh… - Frontiers in …, 2021 - frontiersin.org
Sciatic nerve injury is often associated with neuropathic pain and neuroinflammation in the
central and peripheral nervous systems. In our previous work, Potamogeton perfoliatus L …

Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett Syndrome Mice

JR Whitaker-Fornek, PM Jenkins… - Journal of …, 2023 - journals.physiology.org
Rett syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects females
due to silencing mutations in the X-linked MECP2 gene. One of the most troubling symptoms …

In vivo evidence for the cellular basis of central hypoventilation of Rett syndrome and pharmacological correction in the rat model

Y Wu, N Cui, H Xing, W Zhong… - Journal of Cellular …, 2021 - Wiley Online Library
Rett syndrome (RTT) is a neurodevelopmental disorder caused mostly by mutations in the
MECP2 gene. RTT patients show periodical hypoventilation attacks. The breathing disorder …