The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Ferroptosis is a new form of regulated cell death, which is characterized by the iron‐
dependent accumulation of lethal lipid peroxides and involved in many critical diseases …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How
lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we …

Summary RLR-mediated type I IFN production plays a pivotal role in elevating host immunity
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …

Chemotherapy-resistant human acute myeloid leukemia (AML) cells are thought to be
enriched in quiescent immature leukemic stem cells (LSC). To validate this hypothesis in …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitochondria exist in a dynamic cycle of fusion and fission whose balance directly influences
the morphology of the 'mitochondrial network', a term that encompasses the branched …

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they
act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …