Multiple sclerosis (MS) is an autoimmune disease characterized by recurrent episodes of
demyelination and axonal lesion mediated by CD4+ T cells with a proinflammatory Th1 and …

Alginate is a polysaccharide belonging to the family of linear (unbranched), non-repeating
copolymers, consisting of variable amounts of β-d-mannuronic acid and its C5-epimer α-l …

Reactive oxygen species (ROS) are produced in many normal and abnormal processes in
humans, including atheroma, asthma, joint diseases, cancer, and aging. Basal levels of ROS …

Multiple sclerosis (MS) is an autoimmune disease associated with chronic inflammatory
demyelination of the central nervous system (CNS). Due to disease complexity and …

Reactive oxygen species (ROS) play an important role in various events underlying multiple
sclerosis pathology. In the initial phase of lesion formation, ROS are known to mediate the …

Context: β-d-Mannuronic acid (M2000) has shown its therapeutic effects with the greatest
tolerability and efficacy in various experimental models such as experimental autoimmune …

Metastasis is the main cause of death in breast cancer patients. Inflammatory processes
following crosstalk between tumor cells and tumor microenvironment play an important role …

Known as one of the most sophisticated systems of the human body, the nervous system
consists of neural cells and controls all parts of the body. It is closely related to the immune …

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

The positive impacts of β‐d‐mannuronic acid (M2000) on the gene expression of miR‐155,
its target molecules (SOCS1 and SHIP1), and NF‐κB transcription factor were demonstrated …