Drug shortages continue at crisis levels in the United States, with no end in sight. Extensive
research in disparate areas has been conducted to explore the impact that shortages have …

The maturation of genomic technologies has enabled new discoveries in disease
pathogenesis as well as new approaches to patient care. In pediatric oncology, patients may …

The US Food and Drug Administration's December 2016 approval of nusinersen for the
treatment of patients with all subtypes of spinal muscular atrophy ushered in a new era for …

The coronavirus disease (COVID-19) pandemic has dramatically impacted all aspects of
healthcare delivery (1). There is widespread concern that increased clinical demands due to …

In resource-rich countries, 5-year survival rates for children with cancer approach 85%. This
impressive statistic is largely the result of integrating research with clinical care. At the core …

Shortages of cardiovascular drugs have become increasingly common, representing an
ongoing public health crisis. Given few therapeutic alternatives to many of the drugs in short …

Acute and chronic shortages of various pharmaceuticals and particularly of sterile injectable
products are being reported on a global scale, prompting evaluation of more effective …

Purpose Global data mapping access to essential chemotherapeutics for pediatric cancer
are scarce. We report a survey of international pediatric cancer care providers' access to …

The fundamental pathophysiology of malignancies is dysregulation of the signalling
pathways. Protein tyrosine kinases (PTKs) are among the enzymes which, if mutated, play a …

Background. Even though medications play a major role in the cure, palliation, and inhibition
of disease, they also expose patients to drug‐related problems. Drug‐related problems are …