Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life

ES Donkor - Stroke research and treatment, 2018 - Wiley Online Library
Stroke is ranked as the second leading cause of death worldwide with an annual mortality
rate of about 5.5 million. Not only does the burden of stroke lie in the high mortality but the …

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

R Malik, G Chauhan, M Traylor, M Sargurupremraj… - Nature …, 2018 - nature.com
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Risk and secondary prevention of stroke recurrence: a population-base cohort study

C Flach, W Muruet, CDA Wolfe, A Bhalla, A Douiri - Stroke, 2020 - Am Heart Assoc
Background and Purpose: With recent advances in secondary prevention management,
stroke recurrence rates may have changed substantially. We aim to estimate risks and …

[HTML][HTML] Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study …

HD Sesso, JAE Manson, AK Aragaki, PM Rist… - The American journal of …, 2022 - Elsevier
Background Cocoa extract is a source of flavanols that favorably influence vascular risk
factors in small and short-term trials, yet effects on clinical cardiovascular events are …

Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease

W Herrington, B Lacey, P Sherliker, J Armitage… - Circulation …, 2016 - Am Heart Assoc
Atherosclerosis is a leading cause of vascular disease worldwide. Its major clinical
manifestations include ischemic heart disease, ischemic stroke, and peripheral arterial …

Effect of implantable vs prolonged external electrocardiographic monitoring on atrial fibrillation detection in patients with ischemic stroke: the PER DIEM randomized …

BH Buck, MD Hill, FR Quinn, KS Butcher, BK Menon… - Jama, 2021 - jamanetwork.com
Importance The relative rates of detection of atrial fibrillation (AF) or atrial flutter from
evaluating patients with prolonged electrocardiographic monitoring with an external loop …

Quality of life after stroke: impact of clinical and sociodemographic factors

MJM Ramos-Lima, IC Brasileiro, TL Lima… - Clinics, 2018 - SciELO Brasil
OBJECTIVES: The aim of the study was to analyze the impact of ischemic stroke on health-
related quality of life (QoL) and associate this event with individuals' clinical and …

Atrial fibrillation in patients with cryptogenic stroke

DJ Gladstone, M Spring, P Dorian… - … England Journal of …, 2014 - Mass Medical Soc
Background Atrial fibrillation is a leading preventable cause of recurrent stroke for which
early detection and treatment are critical. However, paroxysmal atrial fibrillation is often …

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden

J Staals, SDJ Makin, FN Doubal, MS Dennis… - Neurology, 2014 - AAN Enterprises
Objectives: In this cross-sectional study, we tested the construct validity of a “total SVD
score,” which combines individual MRI features of small-vessel disease (SVD) in one …