Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124
displays specific temporal and spatial profiles in various cell and tissue types and affects a …

Pediatric and adult high-grade gliomas are the most common primary malignant brain
tumors, with poor prognosis due to recurrence and tumor infiltration after therapy. Quiescent …

Simple Summary In this review, the thorny issue of glioblastoma models is addressed, with a
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …

High-grade diffuse glioma (HGG) is the leading cause of brain tumour death. While the
genetic drivers of HGG have been well described, targeting these has thus far had little …

DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

The mammalian brain is made up of billions of neurons and supporting cells (glial cells),
intricately connected. Molecular perturbations often lead to neurodegeneration by …

During neurogenesis, specific transcription factors are needed to repress neuronal genes in
nonneuronal cells to ensure precise development. Repressor element-1 binding …

The spontaneous expression of neural markers, already demonstrated in bone marrow (BM)
mesenchymal stem cells (MSCs), has been considered as evidence of the MSCs' …

Background The repressor element-1 silencing transcription factor (REST), a master
transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in …