Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of
the idea that asymmetric cell division is a defining characteristic of stem cells that enables …

The Caenorhabditis elegans germ line provides an exceptional model for analysis of the
molecular controls governing stem cell maintenance, the cell cycle transition from mitosis to …

To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile
the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide
range of eukaryotes and has been shown to be required for proper chromosome …

The Caenorhabditis elegans oocyte is a highly amenable system for forward and reverse
genetic analysis of receptor-mediated endocytosis. We describe the use of transgenic …

Most current models propose Sonic hedgehog (Shh) as the primary determinant of
anteroposterior development of amniote limbs. Shh protein is said to be required to direct …

How genes are regulated to produce the correct assortment of proteins for every cell type is
a fundamental question in biology. For many genes, regulation begins at the DNA level with …

Background: Cell-fate determination requires that cells choose between alternative
developmental pathways. For example, germ cells in the nematode worm Caenorhabditis …

Germline stem cells are defined by their unique ability to generate more of themselves as
well as differentiated gametes. The molecular mechanisms controlling the decision between …