Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the white
matter of the human brain caused by lytic infection of oligodendrocytes with the human …

Natalizumab is a highly effective immunomodulator in the treatment of multiple sclerosis
(MS). Treatment with natalizumab has been associated with progressive multifocal …

Background Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute
effective treatment for ulcerative colitis. Methods We conducted two integrated randomized …

Background The efficacy of vedolizumab, an α4β7 integrin antibody, in Crohn's disease is
unknown. Methods In an integrated study with separate induction and maintenance trials …

Objective A study was undertaken to establish an enzyme‐linked immunosorbent assay
(ELISA) to detect JC virus (JCV)‐specific antibodies in multiple sclerosis (MS) patients, and …

From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …

Many neurological diseases of the central nervous system (CNS) are underpinned by
malfunctions of the immune system, including disorders involving opportunistic infections …

Objective: A study was undertaken to define the prevalence of anti‐JC virus (JCV)
antibodies in multiple sclerosis (MS) patients and to evaluate the analytical false‐negative …

Inflammatory bowel disease (IBD) is comprised of Crohn's disease and ulcerative colitis,
both chronic inflammatory intestinal disorders of unknown etiology characterized by a …

Although biologic agents directed against tumor necrosis factor alpha (TNFα) continue to be
an effective therapeutic strategy for patients with inflammatory bowel disease (IBD) …