Peptidyl-tRNA hydrolase is an essential enzyme which acts as one of the rescue factors of
the stalled ribosomes. It is an esterase that hydrolyzes the ester bond in the peptidyl-tRNA …

Bacterial peptidyl tRNA hydrolase (Pth) or Pth1 emerges as a pivotal enzyme involved in the
maintenance of cellular homeostasis by catalyzing the release of peptidyl moieties from …

In bacteria, peptidyl-tRNA hydrolase (Pth, EC 3.1. 1.29) is a ubiquitous and essential
enzyme for preventing the accumulation of peptidyl-tRNA and sequestration of tRNA. Pth is …

Peptidyl-tRNA hydrolase (Pth) cleaves the ester bond between the peptide and the tRNA of
peptidyl-tRNA molecules, which are produced by aborted translation, to recycle tRNA for …

Bacterial peptidyl-tRNA hydrolase (Pth; EC 3.1. 1.29) hydrolyzes the peptidyl-tRNAs
accumulated in the cytoplasm and thereby prevents cell death by alleviating tRNA …

In a cell, peptidyl-tRNA molecules that have prematurely dissociated from ribosomes need to
be recycled. This work is achieved by an enzyme called peptidyl-tRNA hydrolase. To …

All mRNAs cannot be translated into full-length proteins due to ribosome-stalling that leads
to release of peptidyl-tRNA which can be lethal for bacterial survival. The enzyme peptidyl …

Bacterial Pth1 is essential for viability. Pth1 cleaves the ester bond between the peptide and
nucleotide of peptidyl-tRNA generated from aborted translation, expression of mini-genes …

Pooled knockdown libraries of essential genes are useful tools for elucidating the
mechanisms of action of antibacterial compounds, a pivotal step in antibiotic discovery …

With the relentless development of drug resistance and re-emergence of many pathogenic
bacteria, the need for new antibiotics and new antibiotic targets is urgent and growing …