Multi-target drugs: the trend of drug research and development
Summarizing the status of drugs in the market and examining the trend of drug research and
development is important in drug discovery. In this study, we compared the drug targets and …
development is important in drug discovery. In this study, we compared the drug targets and …
Interactive effects of cocaine on HIV infection: implication in HIV-associated neurocognitive disorder and neuroAIDS
S Dahal, SVP Chitti, MPN Nair, SK Saxena - Frontiers in microbiology, 2015 - frontiersin.org
Substantial epidemiological studies suggest that not only, being one of the reasons for the
transmission of the human immunodeficiency virus (HIV), but drug abuse also serves its role …
transmission of the human immunodeficiency virus (HIV), but drug abuse also serves its role …
A phase IIa study evaluating safety, pharmacokinetics, and antiviral activity of GSK2838232, a novel, second-generation maturation inhibitor, in participants with …
E DeJesus, S Harward, RC Jewell… - Clinical Infectious …, 2020 - academic.oup.com
Background GSK2838232 is a second-generation, potent, small-molecule, oral human
immunodeficiency virus type 1 (HIV-1) maturation inhibitor for once-daily administration …
immunodeficiency virus type 1 (HIV-1) maturation inhibitor for once-daily administration …
The safety, tolerability, and pharmacokinetic profile of GSK 2838232, a novel 2nd generation HIV maturation inhibitor, as assessed in healthy subjects
M Johnson, RC Jewell, A Peppercorn… - Pharmacology …, 2018 - Wiley Online Library
This work aimed to assess the safety, tolerability, pharmacokinetics (PK), and relative
bioavailability of GSK 2838232, an investigational HIV maturation inhibitor. GSK 2838232 …
bioavailability of GSK 2838232, an investigational HIV maturation inhibitor. GSK 2838232 …
[HTML][HTML] Molecular Biology and Pathogenesis of Retroviruses
SK Saxena, SV Chitti - Advances in Molecular Retrovirology, 2016 - intechopen.com
Retroviruses consist of a varied family of enveloped RNA viruses with positive-sense RNAs
that replicate in a host cell through the process of reverse transcription. Retroviruses belong …
that replicate in a host cell through the process of reverse transcription. Retroviruses belong …
Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef
SK Saxena, G Shrivastava, S Tiwari, MLA Swamy… - Future …, 2012 - Taylor & Francis
HIV-1 Nef protein is an approximately 27-kDa myristoylated protein that is a virulence factor
essential for efficient viral replication and infection in CD4+ T cells. The functions of CD4+ T …
essential for efficient viral replication and infection in CD4+ T cells. The functions of CD4+ T …
The Literature of Heterocyclic Chemistry, Part XIII, 2012–2013
LI Belen'kii, YB Evdokimenkova - Advances in Heterocyclic Chemistry, 2015 - Elsevier
A systematized review of reviews and monographs published in 2012–2013 on all aspects
of heterocyclic chemistry is given.
of heterocyclic chemistry is given.
NeuroAIDS: mechanisms, causes, prevalence, diagnostics and social issues
SK Saxena, S Tiwari, MPN Nair - Current perspectives in HIV …, 2013 - books.google.com
Human immunodeficiency virus-1 (HIV-1) engulfs 33 millions of life as per the latest UN
AIDS report [Saxena, Tiwari., et al., 2012] and the effect worsens up when it causes …
AIDS report [Saxena, Tiwari., et al., 2012] and the effect worsens up when it causes …
[PDF][PDF] Quantitative Structure Activity Relationship and Molecular Docking of Pim-1 Kinase Inhibitors
H Rathod - Int J Biomed Data Min, 2016 - researchgate.net
QSAR has established itself as an important means of virtual screening. Computational
analysis of numerous drug molecules aided the facility to meaningfully screen specific ones …
analysis of numerous drug molecules aided the facility to meaningfully screen specific ones …
[PDF][PDF] Zika Virus (ZIKV)-An Uncommon Zoonotic Virus
B Parida - 2017 - hakon-art.com
Zika virus (ZIKV) remained a comparatively incomprehensible animal virus to us so far.
During a recent series of outbreaks with severe clinical complications, this virus came into …
During a recent series of outbreaks with severe clinical complications, this virus came into …