Thrombospondins

WA Frazier - Current opinion in cell biology, 1991 - Elsevier
The thrombospondins are a family of proteins generated by alternative splicing and gene
duplication, which contain binding sites for many soluble proteins and up to five cellular …

The role of lysosomal membrane proteins in autophagy and related diseases

J Xu, J Gu, W Pei, Y Zhang, L Wang, J Gao - The FEBS journal, 2024 - Wiley Online Library
As a self‐degrading and highly conserved survival mechanism, autophagy plays an
important role in maintaining cell survival and recycling. The discovery of autophagy‐related …

Single‐Cell RNA Sequencing and Spatial Transcriptomics Reveal Pathogenesis of Meningeal Lymphatic Dysfunction after Experimental Subarachnoid Hemorrhage

X Wang, A Zhang, Q Yu, Z Wang, J Wang… - Advanced …, 2023 - Wiley Online Library
Subarachnoid hemorrhage (SAH) is a devastating subtype of stroke with high mortality and
disability rate. Meningeal lymphatic vessels (mLVs) are a newly discovered intracranial fluid …

[HTML][HTML] THBS1 (thrombospondin-1)

JS Isenberg, DD Roberts - Atlas of genetics and cytogenetics in …, 2020 - ncbi.nlm.nih.gov
Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is
infrequently mutated in most cancers, but its expression is positively regulated by several …

Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.

J Lawler, M Duquette, CA Whittaker, JC Adams… - The Journal of cell …, 1993 - rupress.org
A new member of the thrombospondin gene family, designated thrombospondin-4, has been
identified in the Xenopus laevis genome. The predicted amino acid sequence indicates that …

The functions of thrombospondin and its involvement in physiology and pathophysiology

J Lahav - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1993 - Elsevier
The functions of thrombospondin and its involvement in physiology and pathophysiology
Page 1 Biochimica et Biophysica Acta, 1182 (1993) 1-14 1 © 1993 Elsevier Science …

[HTML][HTML] Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.

HL Vos, S Devarayalu, Y De Vries… - Journal of Biological …, 1992 - Elsevier
A third member of the thrombospondin gene family (Thbs3) has been partially characterized
in the mouse. In both the mouse and humans, the Thbs3/THBS3 gene is located …

Role of matricellular proteins in disorders of the central nervous system

AR Jayakumar, A Apeksha, MD Norenberg - Neurochemical research, 2017 - Springer
Matricellular proteins (MCPs) are actively expressed non-structural proteins present in the
extracellular matrix, which rapidly turnover and possess regulatory roles, as well as mediate …

A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome

P Bornstein, K O'Rourke, K Wikstrom, FW Wolf… - Journal of Biological …, 1991 - Elsevier
The diverse and occasionally conflicting properties described for the extracellular, cell
surface-associated protein thrombospondin (TSP) have raised the possibility that …

Structural characterization of ANGPTL8 (betatrophin) with its interacting partner lipoprotein lipase

A Siddiqa, J Ahmad, A Ali, RZ Paracha, Z Bibi… - … biology and chemistry, 2016 - Elsevier
Abstract Angiopoietin-like protein 8 (ANGPTL8)(also known as betatrophin) is a newly
identified secretory protein with a potential role in autophagy, lipid metabolism and …