[HTML][HTML] Tendon injury and repair–A perspective on the basic mechanisms of tendon disease and future clinical therapy

JG Snedeker, J Foolen - Acta biomaterialia, 2017 - Elsevier
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to
the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive …

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

E Gracey, A Burssens, I Cambré, G Schett… - Nature reviews …, 2020 - nature.com
Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

The pathogenesis of tendinopathy: balancing the response to loading

SP Magnusson, H Langberg, M Kjaer - Nature Reviews Rheumatology, 2010 - nature.com
Tendons are designed to withstand considerable loads. Mechanical loading of tendon tissue
results in upregulation of collagen expression and increased synthesis of collagen protein …

Tendinopathy—from basic science to treatment

G Riley - Nature clinical practice Rheumatology, 2008 - nature.com
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons
possess a highly organized fibrillar matrix, consisting of type I collagen and various' …

Tendinopathy: is imaging telling us the entire story?

SI Docking, CC Ooi, D Connell - journal of orthopaedic & sports physical …, 2015 - jospt.org
Tendinopathy is frequently associated with structural disorganization within the tendon. As
such, the clinical use of ultrasound and magnetic resonance imaging for tendinopathy has …

The basic science of tendinopathy

Y Xu, GAC Murrell - Clinical Orthopaedics and Related Research …, 2008 - journals.lww.com
Tendinopathy is a common clinical problem with athletes and in many occupational settings.
Tendinopathy can occur in any tendon, often near its insertion or enthesis where there is an …

Functional anatomy, histology and biomechanics of the human Achilles tendon—A comprehensive review

K Winnicki, A Ochała-Kłos, B Rutowicz… - Annals of Anatomy …, 2020 - Elsevier
Objectives The aim of this study was to provide a comprehensive overview of the
anatomical, histological, and biomechanical aspects of the Achilles tendon. Methods A …

Beneficial effects of autologous bone marrow-derived mesenchymal stem cells in naturally occurring tendinopathy

RKW Smith, NJ Werling, SG Dakin, R Alam… - PloS one, 2013 - journals.plos.org
Tendon injuries are a common age-related degenerative condition where current treatment
strategies fail to restore functionality and normal quality of life. This disease also occurs …

Isolation and characterization of multipotent rat tendon-derived stem cells

YF Rui, PPY Lui, G Li, SC Fu, YW Lee… - … Engineering Part A, 2010 - liebertpub.com
Stem cells have recently been isolated from humans and mice but not from rat tendon tissue.
This study reports the isolation and characterization of stem cells from rat tendon. Nucleated …

Physiopathology of intratendinous calcific deposition

F Oliva, AG Via, N Maffulli - BMC medicine, 2012 - Springer
In calcific tendinopathy (CT), calcium deposits in the substance of the tendon, with chronic
activity-related pain, tenderness, localized edema and various degrees of decreased range …