The clinical progress of mRNA vaccines and immunotherapies

AJ Barbier, AY Jiang, P Zhang, R Wooster… - Nature …, 2022 - nature.com
The emergency use authorizations (EUAs) of two mRNA-based severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 vaccines approximately 11 months after publication of …

Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19

S Senapati, P Banerjee, S Bhagavatula… - Journal of genetics, 2021 - Springer
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an
emerging global public health crisis. Angiotensin converting enzyme 2 (ACE2) and trans …

In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19

DM Teli, MB Shah, MT Chhabria - Frontiers in molecular biosciences, 2021 - frontiersin.org
Historically, plants have been sought after as bio-factories for the production of diverse
chemical compounds that offer a multitude of possibilities to cure diseases. To combat the …

Structural evaluation of the spike glycoprotein variants on SARS-CoV-2 transmission and immune evasion

MZ Salleh, JP Derrick, ZZ Deris - International journal of molecular …, 2021 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents
significant social, economic and political challenges worldwide. SARS-CoV-2 has caused …

A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses

A Nassar, IM Ibrahim, FG Amin, M Magdy, AM Elgharib… - Molecules, 2021 - mdpi.com
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …

Comparative perturbation-based modeling of the SARS-CoV-2 spike protein binding with host receptor and neutralizing antibodies: Structurally adaptable allosteric …

GM Verkhivker, S Agajanian, DY Oztas, G Gupta - Biochemistry, 2021 - ACS Publications
In this study, we used an integrative computational approach to examine molecular
mechanisms and determine functional signatures underlying the role of functional residues …

Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: modeling and simulation approaches

A Frances-Monerris, C Hognon, T Miclot… - Journal of Proteome …, 2020 - ACS Publications
The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

The development of SARS-CoV-2 variants: the gene makes the disease

R Perez-Gomez - Journal of developmental biology, 2021 - mdpi.com
A novel coronavirus (SARS-CoV-2) emerged towards the end of 2019 that caused a severe
respiratory disease in humans called COVID-19. It led to a pandemic with a high rate of …

Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine

RSL Tan, P Hassandarvish, CF Chee, LW Chan… - Carbohydrate …, 2022 - Elsevier
The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of
people. It is characterized by a widespread infection by the severe acute respiratory …