Bioinspired hydrogels for drug-eluting contact lenses

C Alvarez-Lorenzo, S Anguiano-Igea, A Varela-García… - Acta biomaterialia, 2019 - Elsevier
Efficient ocular drug delivery that can overcome the challenges of topical application has
been largely pursued. Contact lenses (CLs) may act as light-transparent cornea/sclera …

[HTML][HTML] Testing drug release from medicated contact lenses: The missing link to predict in vivo performance

AF Pereira-da-Mota, CM Phan, A Concheiro… - Journal of Controlled …, 2022 - Elsevier
Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms,
but the feasibility of medicated CL development is constrained by numerous scientific …

Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

C Yang, Q Wu, J Liu, J Mo, X Li, C Yang, Z Liu… - Nature …, 2022 - nature.com
Engineering wearable devices that can wirelessly track intraocular pressure and offer
feedback-medicine administrations are highly desirable for glaucoma treatments, yet remain …

Constructing an ultra-rapid nanoconfinement-enhanced fluorescence clinical detection platform by using machine learning and tunable DNA xerogel “Probe”

M Yu, R Ye, T Zeng, L Tan, Z Zhao, W Gao… - Analytical …, 2023 - ACS Publications
Low mass transfer efficiency and unavoidable matrix effects seriously limit the development
of rapid and accurate determination of biosensing systems. Herein, we have successfully …

[HTML][HTML] Contact lens as an emerging platform for ophthalmic drug delivery: A systematic review

H Yang, M Zhao, D Xing, J Zhang, T Fang… - Asian Journal of …, 2023 - Elsevier
The number of people with eye diseases has increased with the use of electronics.
However, the bioavailability of eye drops remains low owing to the presence of the ocular …

Scalable methods for directional assembly of fillers in polymer composites: Creating pathways for improving material properties

A Griffin, Y Guo, Z Hu, J Zhang, Y Chen… - Polymer …, 2022 - Wiley Online Library
Polymer composites are ubiquitous and indispensable in numerous applications. Coupling
the inclusion of reinforcing agents with methods developed to control filler distribution and …

Commercialization challenges for drug eluting contact lenses

OL Lanier, KG Christopher, RM Macoon… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Eye drops are commonly used for delivering ophthalmic drugs despite many
deficiencies including low bioavailability and poor compliance. Contact lenses can deliver …

Contact lenses with dual drug delivery for the treatment of bacterial conjunctivitis

FA Maulvi, SS Singhania, AR Desai, MR Shukla… - International journal of …, 2018 - Elsevier
Currently, bacterial conjunctivitis is treated by frequent administration of antibiotic eye drop
solutions, which is tedious and patient noncompliant. Contact lenses could be ideal medical …

Sustained ophthalmic delivery of highly soluble drug using pH-triggered inner layer-embedded contact lens

Q Zhu, H Cheng, Y Huo, S Mao - International journal of pharmaceutics, 2018 - Elsevier
In the present work the feasibility of using inner layer-embedded contact lenses (CLs) to
achieve sustained release of highly water soluble drug, betaxolol hydrochloride (BH) on the …

Peptide‐Reinforced Amphiphilic Polymer Conetworks

STR Velasquez, D Jang, P Jenkins… - Advanced Functional …, 2022 - Wiley Online Library
Amphiphilic polymer conetworks (APCNs) are polymer networks composed of hydrophilic
and hydrophobic chain segments. Their applications range from soft contact lenses to …