The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19
and are persistent in patients with long COVID experiencing post-acute sequelae of SARS …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from
the influx of plasma components, which may disturb neuronal functions. The BBB is a …

Fibrogenesis is a mechanism of wound healing and repair. However, prolonged injury
causes deregulation of normal processes and results in extensive deposition of extracellular …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

It is becoming increasingly apparent that spatial regulation of cell signalling processes is
critical to normal cellular function. In this regard, cAMP signalling regulates many pivotal …

The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating levels of
the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a …

Chronic liver injury of many etiologies produces liver fibrosis and may eventually lead to the
formation of cirrhosis. Fibrosis is part of a dynamic process associated with the continuous …