The breast stromal microenvironment is a pivotal factor in breast cancer development,
growth and metastases. Although pathologists often detect morphologic changes in stroma …

Background Mammographic density (MD) is one of the strongest breast cancer risk factors.
Its age-related characteristics have been studied in women in western countries, but …

The presence of microcalcifications in the breast microenvironment, combined with the
growing evidences of the possible presence of osteoblast-like or osteoclast-like cells in the …

Background Elevated mammographic breast density is a strong breast cancer risk factor with
poorly understood etiology. Increased deposition of collagen, one of the main fibrous …

In mice, the lack of secreted frizzled-related protein 1 (SFRP1) is responsible for
mammogenesis and hyperplasia, while, in bovines, its overexpression is associated with …

Lesser degrees of terminal duct-lobular unit (TDLU) involution predict higher breast cancer
risk; however, standardized measures to quantitate levels of TDLU involution have only …

Background Emerging data indicate that variations in quantitative epithelial and stromal
tissue composition and their relative abundance in benign breast biopsies independently …

Background Exposure to certain outdoor air pollutants may be associated with a higher risk
of breast cancer, though potential underlying mechanisms are poorly understood. We …

Purpose We evaluated the association of percent mammographic density (PMD), absolute
dense area (DA), and non-dense area (NDA) with risk of “intrinsic” molecular breast cancer …

Background Over 40% of women undergoing breast screening have mammographically
dense breasts. Elevated mammographic breast density (MBD) is an established breast …