Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

New Findings What is the topic of this review? This report describes changes in cardiac and
skeletal muscle energy metabolism that occur with exposure to high altitude and considers …

Suicide and major depressive disorder (MDD) are complex conditions that almost certainly
arise from the influences of many interrelated factors. There are significant regional …

Background Heart failure due to diastolic dysfunction exacts a major economic, morbidity
and mortality burden in the United States. Therapeutic agents to improve diastolic …

Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP)
and decreases left-ventricular (LV) volumes. However, relatively little is known of the long …

Aims PERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We
previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 …

Key points Exposure to environmental hypoxia, at high altitude or in a chamber, impairs
cardiac energetics and alters mitochondrial function. Inorganic nitrate, a ubiquitous dietary …

Myocardial hypoxia is a major factor in the pathology of cardiac ischemia and myocardial
infarction. Hypoxia also occurs in microvascular disease and cardiac hypertrophy, and is …

Background Evidence regarding the relationship between in-hospital mortality and SpO2
was low oxygen saturations are often thought to be harmful, new research in patients with …

Background There has been considerable debate as to whether different modalities of
simulated hypoxia induce similar cardiac responses. Materials and Methods This was a …