Protein arginine deiminases and associated citrullination: physiological functions and diseases associated with dysregulation
EE Witalison, PR Thompson… - Current drug targets, 2015 - ingentaconnect.com
Human proteins are subjected to more than 200 known post-translational modifications
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …
(PTMs)(eg, phosphorylation, glycosylation, ubiquitination, S-nitrosylation, methylation …
[HTML][HTML] p53 and metabolism: from mechanism to therapeutics
The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer
BA Boone, L Orlichenko, NE Schapiro… - Cancer gene …, 2015 - nature.com
Neutrophil extracellular traps (NETs) are formed when neutrophils expel their DNA, histones
and intracellular proteins into the extracellular space or circulation .NET formation is …
and intracellular proteins into the extracellular space or circulation .NET formation is …
[HTML][HTML] A multi-targeted approach to suppress tumor-promoting inflammation
Cancers harbor significant genetic heterogeneity and patterns of relapse following many
therapies are due to evolved resistance to treatment. While efforts have been made to …
therapies are due to evolved resistance to treatment. While efforts have been made to …
Understanding the mechanisms by which epigenetic modifiers avert therapy resistance in cancer
A Quagliano, A Gopalakrishnapillai, SP Barwe - Frontiers in oncology, 2020 - frontiersin.org
The development of resistance to anti-cancer therapeutics remains one of the core issues
preventing the improvement of survival rates in cancer. Therapy resistance can arise in a …
preventing the improvement of survival rates in cancer. Therapy resistance can arise in a …
miRNA-15a/16: as tumor suppressors and more
E Huang, R Liu, Y Chu - Future oncology, 2015 - Taylor & Francis
Since their first discovery in chronic lymphocytic leukemia, miR-15a and miR-16 have been
reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This …
reported to act as tumor suppressors or potential oncomiRs in different types of cancer. This …
PAD4: pathophysiology, current therapeutics and future perspective in rheumatoid arthritis
S Koushik, N Joshi, S Nagaraju… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Peptidyl arginine deiminase 4 (PAD4) is an enzyme that plays an important role
in gene expression, turning out genetic code into functional products in the body. It is …
in gene expression, turning out genetic code into functional products in the body. It is …
Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model
Y Seri, H Shoda, A Suzuki, I Matsumoto, T Sumida… - Scientific reports, 2015 - nature.com
Abstract Peptidyl arginine deiminase 4 (PAD4) is an enzyme that is involved in protein
citrullination and is a target for anti-citrullinated peptide antibodies (ACPAs) in rheumatoid …
citrullination and is a target for anti-citrullinated peptide antibodies (ACPAs) in rheumatoid …
Peptidylarginine deiminases—roles in cancer and neurodegeneration and possible avenues for therapeutic intervention via modulation of exosome and microvesicle …
S Lange, M Gallagher, S Kholia… - International journal of …, 2017 - mdpi.com
Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from
cells and participate in cell-to-cell communication via transport of biological molecules …
cells and participate in cell-to-cell communication via transport of biological molecules …
LncRNA CDKN2B-AS1 relieved inflammation of ulcerative colitis via sponging miR-16 and miR-195
Y Tian, L Cui, C Lin, Y Wang, Z Liu, X Miao - International …, 2020 - Elsevier
Background This study was aimed to explore the differential expression of lncRNA CDKN2B-
AS1-miR-195-5p/miR-16-5p axis in ulcerative colitis (UC) and its role in regulating UC …
AS1-miR-195-5p/miR-16-5p axis in ulcerative colitis (UC) and its role in regulating UC …