Background: Liver transplantation is a lifesaving procedure for patients with end-stage liver
disease (ESLD). However, many patients never receive a transplant due to insufficient donor …

Current machine perfusion technology permits livers to be preserved ex situ for short periods
to assess viability prior to transplant. Long-term normothermic perfusion of livers is an …

Recent advances in machine perfusion have revolutionised the field of transplantation by
prolonging preservation, permitting evaluation of viability prior to implant and rescue of …

Liver transplantation is the only life-saving procedure for children with end-stage liver
disease. The field is however heterogenic with various graft types, recipient age, weight, and …

Abstract Hypothermic Oxygenated machine PErfusion (HOPE) has recently emerged as a
preservation technique which can reduce ischemic injury and improve clinical outcomes …

Bile duct regeneration is hypothesized to prevent biliary strictures, a leading cause of
morbidity after liver transplantation. Assessing the capacity for biliary regeneration may …

Developing clinically predictive model systems for evaluating gene transfer and gene editing
technologies has become increasingly important in the era of personalized medicine. Liver …

Background Ex situ machine perfusion facilitates the assessment of livers prior to
transplantation. However, currently available markers of liver function poorly predict long …

Background Normothermic machine perfusion (NMP) allows for the assessment and
resuscitation of ex‐vivo human livers prior to transplantation. Commercially available NMP …

Background. Normothermic liver machine perfusion (NLMP) is advancing the field of liver
transplantation (LT). Beyond improved preservation and organ assessment, NLMP helps to …