Sex‐based differences in severity and mortality in COVID‐19
The current coronavirus disease (COVID‐19) pandemic caused by novel severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and …
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has a male bias in severity and …
SeXX matters in immunity
JG Markle, EN Fish - Trends in immunology, 2014 - cell.com
The significant contributions of sex to an immune response, specifically in the context of the
sex bias observed in susceptibility to infectious and autoimmune diseases and their …
sex bias observed in susceptibility to infectious and autoimmune diseases and their …
Viral load and heterosexual transmission of human immunodeficiency virus type 1
Background and Methods We examined the influence of viral load in relation to other risk
factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In …
factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In …
[HTML][HTML] Heterogeneous escape from X chromosome inactivation results in sex differences in type I IFN responses at the single human pDC level
SH Hagen, F Henseling, J Hennesen, H Savel… - Cell reports, 2020 - cell.com
Immune responses differ between women and men, and type I interferon (IFN) responses
following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise …
following Toll-like receptor 7 (TLR7) stimulation are higher in women. The precise …
Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1
A Meier, JJ Chang, ES Chan, RB Pollard, HK Sidhu… - Nature medicine, 2009 - nature.com
Manifestations of viral infections can differ between women and men, and marked sex
differences have been described in the course of HIV-1 disease. HIV-1–infected women …
differences have been described in the course of HIV-1 disease. HIV-1–infected women …
Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy
Background The relationship between the timing of the initiation of antiretroviral therapy
(ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of …
(ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of …
Sex differences in HIV infection
EP Scully - Current HIV/AIDS Reports, 2018 - Springer
Abstract Purpose of Review This review will outline the multilevel effects of biological sex on
HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential …
HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential …
[HTML][HTML] Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-α production in women
M Griesbeck, S Ziegler, S Laffont, N Smith… - The Journal of …, 2015 - journals.aai.org
Increased IFN-α production contributes to the pathogenesis of infectious and autoimmune
diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 …
diseases. Plasmacytoid dendritic cells (pDCs) from females produce more IFN-α upon TLR7 …
The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling
C Seillet, S Laffont, F Trémollières… - Blood, The Journal …, 2012 - ashpublications.org
Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFN-α/β) in
response to viral or endogenous nucleic acids through activation of their endosomal Toll-like …
response to viral or endogenous nucleic acids through activation of their endosomal Toll-like …
Predictors of disease progression in HIV infection: a review
SE Langford, J Ananworanich, DA Cooper - AIDS research and therapy, 2007 - Springer
During the extended clinically latent period associated with Human Immunodeficiency Virus
(HIV) infection the virus itself is far from latent. This phase of infection generally comes to an …
(HIV) infection the virus itself is far from latent. This phase of infection generally comes to an …