A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …

Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …

Available treatment methods have shown little effect on the burden associated with mental
health disorders. We review promising universal, selective, and indicated preventive mental …

The quality of the interparental relationship is recognized as an important influence on child
and adolescent psychopathology. Historically, clinically oriented research on this topic has …

This review examines mechanisms contributing to the intergenerational transmission of self-
regulation. To provide an integrated account of how self-regulation is transmitted across …

Early life stress (ELS) is a major public health issue, as the consequences often persist into
adulthood and impose negative effects on wide range of outcomes. 1–4 The FinnBrain Birth …

Alexithymia refers to difficulties identifying and describing one's emotions. Growing evidence
suggests that alexithymia is a key transdiagnostic risk factor. Despite its clinical importance …

Stress generation theory initially posited that depression elevates risk for some stressful
events (ie, dependent events) but not others (ie, independent events). This preregistered …

Childhood trauma is a key risk factor for psychopathology. However, little is known about
how exposure to childhood trauma is translated into biological risk for psychopathology …

This report calls on the nation—its leaders, its mental health research and service provision
agencies, its schools, its primary care medical systems, its community-based organizations …