Characterized by a surplus of whole-body adiposity, obesity is strongly associated with the
prognosis of atherosclerosis, a hallmark of coronary artery disease (CAD) and the major …

Obesity results in many health complications. Accumulating evidence indicates that the
obese state is characterized by chronic low-grade inflammation, thereby leading to the …

Maintaining proper energy balance in mammals entails intimate crosstalk between various
tissues and organs. These inter-organ communications are mediated, to a great extent, by …

Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and
pancreas play an important role in the development of insulin resistance, impaired glucose …

Diabetes mellitus (DM) displays a high morbidity. The diabetic heart is susceptible to
myocardial ischemia/reperfusion (MI/R) injury. Impaired activation of prosurvival pathways …

Abstract Purpose of Review In recent years, a family of adiponectin paralogs designated as
C1q/TNF-related protein (CTRP) has attracted increasing attention. They are inflammatory …

Obesity leads to the development of cardiovascular diseases. Adipose tissue produces
various bioactive molecules, also known as adipokines, and imbalanced production of …

Obesity is associated with chronic low-grade inflammation, and metabolic regulators linking
obesity to inflammation have therefore received much attention. Secreted C1q/TNF-related …

Over the past decades, there has been a major increase in type 2 diabetes (T2D)
prevalence in most regions of the world. Diabetic patients are more prone to cardiovascular …

Transgenic overexpression of CTRP9, a secreted hormone downregulated in obesity,
confers striking protection against diet-induced obesity and type 2 diabetes. However, the …