At present, six groups of chronic pulmonary hypertension (PH) are described. Among these,
group 1 (and 1′) comprises a group of diverse diseases termed pulmonary arterial …

Statins, among the most commonly prescribed drugs worldwide, are cholesterol-lowering
agents used to manage and prevent cardiovascular and coronary heart diseases. Recently …

Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived
from the breakdown of extracellular matrix (ECM), which shares sequence and structural …

The pulmonary arteries (PA) in pulmonary arterial hypertension (PAH) are constricted and
remodeled;. They have suppressed apoptosis, partly attributable to suppression of the bone …

Rationale: Platelet-derived growth factor (PDGF) promotes the proliferation and migration of
pulmonary artery smooth muscle cells (PASMCs), and may play a role in the progression of …

Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive
obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure …

Recent investigations have suggested that it might be possible to reverse the pathology of
pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal …

Chronic obstructive pulmonary disease (COPD) and heart failure (CHF) are common
conditions. The prevalence of COPD ranges from 20% to 30% in patients with CHF. The …

Pulmonary arterial hypertension (PAH) is characterized by genetic and acquired
abnormalities that suppress apoptosis and enhance cell proliferation in the vascular wall …