Background—Infective endocarditis is a potentially lethal disease that has undergone major
changes in both host and pathogen. The epidemiology of infective endocarditis has become …

Infective endocarditis is defined by a focus of infection within the heart and is a feared
disease across the field of cardiology. It is frequently acquired in the health care setting, and …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through November 2012, and other …

Infective endocarditis (IE), initially described more than 350 years ago, involves infection of
the endocardial surface of the heart. The clinical manifestations of IE can involve every …

Potential Biases Most studies of IE are affected by selection, survival, and referral bias. They
make it difficult to study the natural history of IE in the general population, because treated …

Staphylococcus aureus bacteremia (SAB) is an important infection with an incidence rate
ranging from 20 to 50 cases/100,000 population per year. Between 10% and 30% of these …

Background The timing and indications for surgical intervention to prevent systemic
embolism in infective endocarditis remain controversial. We conducted a trial to compare …

Before the 1970s, 30% to 50% of US children with IE had underlying rheumatic heart
disease. 9 Because the prevalence of rheumatic heart disease has declined in developed …