Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

Dopamine (DA) releasing midbrain neurons are essential for multiple brain functions, such
as voluntary movement, working memory, emotion and cognition. DA midbrain neurons …

Calcium signaling in neurons as in other cell types can lead to varied changes in cellular
function. Neuronal Ca2+ signaling processes have also become adapted to modulate the …

Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

Calcium signalling plays a crucial role in the control of neuronal function and plasticity.
Changes in neuronal Ca 2+ concentration are detected by Ca 2+-binding proteins that can …

Background Previous studies have implicated the cyclic adenosine monophosphate/protein
kinase A pathway as well as FosB and dynorphin-B expression mediated by dopamine D 1 …

Neuronal calcium sensors (NCSs) are the family of EF-hand proteins mediating Ca2+-
dependent signaling pathways in healthy neurons and neurodegenerative diseases. It was …

In the nervous system, calcium signals play a major role in the conversion of synaptic stimuli
into transcriptional responses. Signal-regulated gene transcription is fundamental for a …

Glioblastomas (GBMs) are the most aggressive and lethal primary astrocytic tumors in
adults, with very poor prognosis. Recurrence in GBM is attributed to glioblastoma stem-like …

The interaction of the activating transcription factor 6 (ATF6), a key effector of the unfolded
protein response (UPR) in the endoplasmic reticulum, with the neuronal calcium sensor …