Adenoviruses have been studied intensively for over 50 years as models of virus–cell
interactions and latterly as gene vectors. With the advent of more sophisticated structural …

Adenovirus (AdV) capsid organization is considerably complex, not only because of its large
size (~ 950 Å) and triangulation number (pseudo T= 25), but also because it contains four …

Construction of a complex virus may involve a hierarchy of assembly elements. Here, we
report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by …

A new method for proteolytic stable isotope labeling is introduced to provide quantitative and
concurrent comparisons between individual proteins from two entire proteome pools or their …

Adenoviral vectors have a number of advantages such as their ability to infect post‐mitotic
tissues. They are produced at high titers and are currently used in 28% of clinical protocols …

We show here that UV absorbance of denatured adeno-associated virus (AAV) vector
provides a simple, rapid, and direct method for quantifying vector genomes and capsid …

Human gene therapy (HGT) is defined as the transfer of nucleic acids (DNA) to somatic cells
of a patient which results in a therapeutic effect, by either correcting genetic defects or by …

The global analysis of cellular proteins has recently been termed proteomics and is a key
area of research that is developing in the post‐genome era. Proteomics uses a combination …

The field of gene therapy is rapidly expanding with a major focus on the treatment of cancer.
Replication-defective adenoviruses are vectors of choice for delivering corrective genes into …

A detailed structural analysis of the entire human adenovirus capsid has been stymied by
the complexity and size of this 150 MDa macromolecular complex. Over the past 10 years …