Alzheimer's disease (AD) currently presents one of the biggest healthcare issues in the
developed countries. There is no effective treatment capable of slowing down disease …

Abstract Alzheimer's disease (AD), the leading cause of dementia, has reached epidemic
proportions, with major social, medical and economical burdens. With no currently available …

The frailty syndrome has recently attracted attention of the scientific community and public
health organizations as precursor and contributor of age-related conditions (particularly …

Background Older people suffering from dementia are at increased risk of malnutrition due
to various nutritional problems, and the question arises which interventions are effective in …

Polyunsaturated fatty acids (PUFAs) are lipid derivatives of omega-3 (docosahexaenoic
acid, DHA, and eicosapentaenoic acid, EPA) or of omega-6 (arachidonic acid, ARA) …

Ketone bodies, the products of fat metabolism, are a source of energy for the brain and are
available even when glucose supplies are inadequate (such as with severe carbohydrate …

Glycerophospholipids and sphingolipids participate in a variety of indispensable metabolic,
neurological, and intracellular signaling processes. In this didactic paper we review the …

Synapse loss and synaptic dysfunction are pathological processes already involved in the
early stages of Alzheimer's disease (AD). Synapses consist principally of neuronal …

The performance of the human brain is based on an interplay between the inherited
genotype and external environmental factors, including diet. Food and nutrition, essential in …

Background: Evidence whether single “cognitive health” foods could prevent cognitive
decline is limited. We investigated whether dietary intake of red wine, white wine, coffee …