DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …

5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide
variety of neoplasms. Non-coding RNAs have a central impact on the determination of the …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

Retinitis pigmentosa (RP) is an inherited retinopathy. Nevertheless, non-genetic biological
factors play a central role in its pathogenesis and progression, including inflammation …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Subcellular compartmentalization contributes to the organization of a plethora of molecular
events occurring within cells. This can be achieved in membraneless organelles generated …

Protein and DNA have been considered as the major components of chromatin. But beyond
that, an increasing number of studies show that RNA occupies a large amount of chromatin …

Mechanistic studies in DNA repair have focused on roles of multi-protein DNA complexes,
so how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood. Yet …

Once thought of as arising from “junk DNA,” non-coding RNAs (ncRNAs) have emerged as
key molecules in cellular processes and response to stress. From diseases such as cancer …

Radiotherapy is a cancer treatment that applies high doses of ionizing radiation to induce
cell death, mainly by triggering DNA double-strand breaks. The outcome of radiotherapy …